Pharmacokinetic Modeling
Pharmacokinetic Modeling
The one- and two-compartment pharmacokinetic models give the concentration profile of a drug in the body for a given dosing scheme. The area under these curves corresponds to the total exposure to the drug. The therapeutic window for a drug is the range between the effective dose and the toxic dose. The dosing scheme for a drug is designed to attain the target concentrations within the therapeutic window. The therapeutic window in this Demonstration is preset, but it is different for each drug. Drug elimination reactions can have varying reaction orders and associated rate constants depending on the system. Drugs are often absorbed in the first compartment when administered orally; the drug must first be absorbed in the stomach before entering the blood stream.