WOLFRAM|DEMONSTRATIONS PROJECT

Morris-Lescar Model of Membranes with Multiple Ion Channels

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applied current
159
initial membrane voltage V(0)
-60
initial fraction of open channels w(0)
0.5
relaxation rate of w
0.04
passive leak
2
Application of various depolarizing currents to barnacle muscle fibers produces spikes or oscillations for some values of the applied current. The Morris–Lescar model, which is a simplified version of the Hodgkin–Huxley model, involves a fast-activating calcium current; a slow potassium current, which is coupled to the calcium current; and a passive leak. The nonlinear simultaneous differential equations display bifurcation corresponding to these modes of behavior for various values of the relevant parameters.