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WOLFRAM|DEMONSTRATIONS PROJECT

Model of Electrical Activity in Human Pancreatic Beta Cells

​
β cell function parameters
ATP production (u.a)
glucose sensitivity (mM)
Glucose
glucose (mM)
basal [ATP] (μM)
Ionic channel conductances (pS)
gKATP
gKCaB
gKCa
gKDr
gKHerg
gNa
gNaB
gCaL
gCaP
gCaT
Ionic currents
ICaL
ICaT
ICaP
IKATP
IKCa
IKCaB
IKDr
IKher
INa
INab
IPCa
​
initital time
final time
time in milliseconds
This Demonstration shows how a simulated human
β
cell behaves in terms of electrical activity and insulin secretion at different glucose levels. It is also possible to simulate the effect of the blockage of the ionic channels by changing their conductances.
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