Genetic Toggle Switch

duration

30.

production rate ÷ degradation rate

3.

initial concentration of repressor 1

1.01

initial concentration of repressor 2

0.99

Hill function exponent

2

This Demonstration implements a mathematical model of the "genetic toggle switch" gene network. The genetic toggle switch consists of two genes, each of which encodes for a protein that represses the other's gene expression. Because of the even number of components in the circuit, there is a net positive feedback, which can give rise to bistable behavior for certain parameter values. The behavior of each repressor concentration is visualized as a function of time.