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Risk of Unexpected Donor Infection: Quarantine Adjusted Window Period Visualisation Tool
Nucelic Acid Test Assay
Select Virus of interest
Virus
HCV
HBV
HIV
Minimum Infective Concentration:
Nb: Assumes minimum infective concentration of 1 virion per innoculum volume:
Innoculum Volume
4,600mls (TBPV)
20mLs (PRBC)
TBPV: Total Body Plasma Volume, PRBC: Packed Red Blood Cell.
Donor Factors
Critical Care Interval (Admission to blood draw (Days))
Interval
1
Deferral Interval
2
Select Donor Region
Region
Australia
North America
Select increased risk behaviour
Risk Behaviour:
MSM
PWID
Sex Work
HRSP
Incarceration
MSM: Men who have sex with men, PWID: Persons who inject drugs, HRSP: Higher risk sexual partner.
Model Constants
Vdt
0.45000000000000000000
X50
3.0600000000000000000
X95
10.200000000000000000
Mic
1
4600
Inc
0.9
Vdt:Viral Doubling Time, X50: X50 Limit of Detection,X95: X95 Limit of detection, Mic: Minimum infective concentration.Inc: Incidence Rate (100PY).
Help
Visualisation:
Areas under the curve:
The Assay's Window Period is 6.2 day(s)
Initial Risk Estimation:
For a Critical Care Admission Length of 1 days,
there are 5.2 days of exposure in the community.
The risk of undetected donor infection is 0.000 128 246
This equates to approximately 1 in 7,797.
Alternative Deferred Blood Draw
For a Critical Care Admission Length of '2 days,
there are 4.2 days of exposure in the community.
The risk of undetectedted donor infection is 0.000103591
This equates to approximately 1 in 9,653.
Number Needed to Defer Analysis
The number needed to defer to prevent 1 organ donor progressing to retrieval surgery with an undetected infection is: 40,560
For full details: Refer to 'The impact of critical care quarantine on the residual risk of unexpected organ donor blood-borne virus infection.' Dutch et al 2025.