Pharmacokinetics of Drug Clearance

dosage (mg)

0.1

volume of distribution (L/kg)

0.1

clearance (L/hr)

0.1

drug conc. at t = 0 hr

drug conc. at t = .5 hr

This Demonstration shows the variation of drug concentration in human plasma of an IV bolus-administered drug over a one-hour time period. Drug-plasma concentration is dependent on the dosage (dose), volume of distribution (Vd) and clearance of the drug (CL). The volume of distribution determines the drug's plasma concentration, while clearance describes the speed in which the drug is cleared from the plasma by the body. This Demonstration might be used as a reference for medical personnel to estimate how quickly an administered drug is processed by the human body. A body mass of 70 kg is assumed.

Details

Snapshot 1: pharmacokinetics of cannabinoids; clearance (L/hr) = 14, volume of distribution (L/kg) = 10 and dosage (mg) = 5

Snapshot 2: pharmacokinetics of albuterol; clearance (L/hr) = 29, volume of distribution (L/kg) = 2.2 and dosage (mg) = 2.5

Snapshot 3: pharmacokinetics of sertraline; clearance (L/hr) = 76, volume of distribution (L/kg) = 20 and dosage(mg) = 25

Snapshot 4: pharmacokinetics of trazodone; clearance (L/hr) = 6, volume of distribution (L/kg) = 1 and dosage (mg) = 30

External Links

Transdermal Drug Delivery by Diffusion

Pharmacokinetic Model for Oral Bioavailability of Aspirin

Diffusion Rates Across the Blood-Brain Barrier

Permanent Citation

Morgan DeMeulemeester, Selina Lu, Lily Haghpassand

"Pharmacokinetics of Drug Clearance"
http://demonstrations.wolfram.com/PharmacokineticsOfDrugClearance/
Wolfram Demonstrations Project
Published: December 16, 2022