Chay-Keizer Model for Electrical Activity of Pancreatic Beta Cell

ionic channel conductances (mS/

2

cm

)

gCa

6.5

gK

12

gkCa

0.09

gl

0.04

Ca2+ extrusion (kca, glucose parameter)

kCa (1/ms)

none

low

medium

high

ionic currents

Ca2+ current

K+ current

KCa current

leak current

Na+/K+ pump

Iapp µA/

2

cm



0

-0.6

plot times

t

p

1

4000

t

p

2

40000

This Demonstration implements the first model of the electrical activity of the pancreatic

β

cell. Although it is a minimal model, it still is capable of reproducing the electric response of the cell at different glucose levels.